Psychopathy is considered to be one of the most resistant to psychotherapy personality disorders. Therapeutic pessimism in this field supports findings from effectiveness institutional correction programmes in offenders with psychopathic traits. Moreover, psychopathy is a salient risk factor for recidivism as well as strong predictive risk factor for criminal violence. The aim of article is to present some practical implications for psychotherapy of psychopathic personality disorder based on review of empirical settings. The influence of factors blocking therapeutic process is discussed. Furthermore, there are discussed perspectives of psychotherapy psychopathy mainly in the context of the application of cognitive-behavioral therapy. Theoretical background for the consideration is based on contemporary approach to the psychopathy including two-factors model of psychopathy and Psychopathy Checklist - Revised (PCL-R) R. D. Hare. Nowadays this approach to the psychopathic personality disorder is regarded as a leading direction in clinical diagnosis, and also in research of effectiveness of treatment and psychotherapy of psychopathy.